abstract：BACKGROUND:Increasing evidence links postoperative cognitive dysfunction (POCD) to surgery and anesthesia. POCD is recognized as an important neuropsychological adverse outcome in surgical patients, particularly the elderly. This prospective cohort study aimed to investigate whether POCD is associated with impaired int...

journal_title：Anesthesia and analgesia

authors： Goettel N,Burkhart CS,Rossi A,Cabella BC,Berres M,Monsch AU,Czosnyka M,Steiner LA

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether mechanically ventilated trauma patients with a positive urine drug screen (UDS) for cocaine and/or amphetamines have different opioid analgesic and sedative requirements compared with similar patients with a negative drug screen for these stimulants. METHOD...

journal_title：Anesthesia and analgesia

authors： Kram B,Kram SJ,Sharpe ML,James ML,Kuchibhatla M,Shapiro ML

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Asian American/Pacific Islanders (AAPIs) are the fastest-growing racial group in the United States. Despite a higher socioeconomic status, AAPI women experience higher rates of maternal morbidity and mortality. METHODS:Using the National Inpatient Sample, we performed a retrospective cohort analysis of wome...

journal_title：Anesthesia and analgesia

authors： Siddiqui M,Minhaj M,Mueller A,Tung A,Scavone B,Rana S,Shahul S

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Although music is frequently used to promote a relaxing environment during labor and delivery, the effect of its use during the placement of neuraxial techniques is unknown. Our study sought to determine the effects of music use on laboring parturients during epidural catheter placement, with the hypothesis ...

journal_title：Anesthesia and analgesia

authors： Drzymalski DM,Tsen LC,Palanisamy A,Zhou J,Huang CC,Kodali BS

更新日期：2017-02-01 00:00:00

abstract：:Bispectral Index Scale (BIS)-guided closed-loop delivery of anesthetics has been extensively studied. We performed a meta-analysis of all the randomized clinical trials comparing efficacy and performance between BIS-guided closed-loop delivery and manually controlled administration of total IV anesthesia. Scopus, PubM...

journal_title：Anesthesia and analgesia

authors： Pasin L,Nardelli P,Pintaudi M,Greco M,Zambon M,Cabrini L,Zangrillo A

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Inhibitors of cyclooxygenase, which block the formation of prostaglandin (PG) E2, are the standard treatment of inflammatory pain. These drugs, however, have serious gastrointestinal, renal, and cardiovascular side effects that limit their clinical use. Cyclodextrins are neutral glucose oligomers that form a...

journal_title：Anesthesia and analgesia

authors： Sauer RS,Rittner HL,Roewer N,Sohajda T,Shityakov S,Brack A,Broscheit JA

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Blood product transfusion is the most commonly performed hospital procedure. Intraoperative blood product utilization varies between institutions and anesthesiologists. In the United States in 2011, nearly 4 million plasma units were transfused. METHODS:A retrospective analysis of intraoperative plasma orde...

journal_title：Anesthesia and analgesia

authors： Meyer MJ,Dzik WH,Levine WC

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Although the bronchodilatory actions of volatile anesthetics, such as halothane, isoflurane, and sevoflurane, have been well documented in previous studies, the properties of desflurane remain controversial. The aim of this study was to investigate the effects of desflurane at different concentrations and du...

journal_title：Anesthesia and analgesia

authors： Zhou J,Iwasaki S,Yamakage M

更新日期：2017-02-01 00:00:00

abstract：:In this article, we describe the role of "clinical scenario" information to assure the safety of interoperable systems, as well as the system's ability to deliver the requisite clinical functionality to improve clinical care. Described are methods and rationale for capturing the clinical needs, workflow, hazards, and ...

journal_title：Anesthesia and analgesia

authors： Weininger S,Jaffe MB,Rausch T,Goldman JM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Superoxide, nitric oxide (NO), and peroxynitrite are important mediators in the pathogenesis of ischemia-reperfusion (I/R) injury. We tested the renoprotective effects of allopurinol (ALP), a xanthine oxidase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), and 5,10,15,20-tetrakis (N-methyl-4-pyridyl) po...

journal_title：Anesthesia and analgesia

authors： Choi EK,Jung H,Kwak KH,Yi SJ,Lim JA,Park SH,Park JM,Kim S,Jee DL,Lim DG

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Current respiratory monitoring technologies such as pulse oximetry and capnography have been insufficient to identify early signs of respiratory compromise in nonintubated patients. Pulse oximetry, when used appropriately, will alert the caregiver to an episode of dangerous hypoxemia. However, desaturation l...

journal_title：Anesthesia and analgesia

authors： Williams GW 2nd,George CA,Harvey BC,Freeman JE

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Obesity causes multiorgan dysfunction, specifically metabolic abnormalities in the liver. Obese patients are opioid-sensitive and have high rates of respiratory complications after surgery. Obesity also has been shown to cause resistance to leptin, an adipose-derived hormone that is key in regulating hunger,...

journal_title：Anesthesia and analgesia

authors： Dalesio NM,Hendrix CW,McMichael DH,Thompson CB,Lee CK,Pho H,Arias RS,Lynn RR,Galinkin J,Yaster M,Brown RH,Schwartz AR

更新日期：2016-12-01 00:00:00

abstract：:Fluid resuscitation is one of the most prevalent treatment in critical care. There is not definitive evidence about the best fluid for resuscitation. The aim of this review will be to asses the efficacy and safety of buffered solution versus saline. We will perform an electronic search in Medline, Embase, and Central....

journal_title：Anesthesia and analgesia

authors： Barea-Mendoza JA,Antequera AM,Plana MN,Chico-Fernández M,Muriel A,Sáez I,Estrada-Lorenzo JM,Montejo-González JC

更新日期：2016-12-01 00:00:00

abstract：:This article describes practices in patient blood management (PBM) in 4 countries on different continents that may provide insights for anesthesiologists and other physicians working in global settings. The article has its foundation in the proceedings of a session at the 2014 AABB annual meeting during which internat...

journal_title：Anesthesia and analgesia

authors： Eichbaum Q,Murphy M,Liu Y,Kajja I,Hajjar LA,Smit Sibinga CT,Shan H

更新日期：2016-12-01 00:00:00

abstract：:A quest for a systems-level neuroscientific basis of anesthetic-induced loss and return of consciousness has been in the forefront of research for the past 2 decades. Recent advances toward the discovery of underlying mechanisms have been achieved using experimental electrophysiology, multichannel electroencephalograp...

journal_title：Anesthesia and analgesia

authors： Hudetz AG,Mashour GA

更新日期：2016-11-01 00:00:00

abstract：:Dilation of lymphatic vessels may contribute to iatrogenic dissemination of cancer cells during surgery. We sought to determine whether neuraxial anesthesia reduces regional lymphatic flow. Using nuclear lymphoscintigraphy, 5 participants receiving spinal anesthesia for brachytherapy had lower extremity lymph flow at ...

journal_title：Anesthesia and analgesia

authors： Hiller JG,Ismail HM,Hofman MS,Narayan K,Ramdave S,Riedel BJ

更新日期：2016-11-01 00:00:00

abstract：:Spine surgery has been growing rapidly as a neurosurgical operation, with an increase of 220% over a 15-year period. Intraoperative blood transfusion is a major outcome determinant of spine procedures. Various approaches, including pharmacologic and nonpharmacologic therapies, have been tested to decrease both intraop...

journal_title：Anesthesia and analgesia

authors： Willner D,Spennati V,Stohl S,Tosti G,Aloisio S,Bilotta F

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Hypotension remains a frequent complication of spinal anesthesia, increasing the risk of nausea and vomiting, altered mental status, and aspiration. The aim of this systematic review and meta-analysis was to determine whether 5-hydroxytryptamine3 (5-HT3) receptor antagonists, administered before the initiati...

journal_title：Anesthesia and analgesia

authors： Heesen M,Klimek M,Hoeks SE,Rossaint R

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Recent attention to adverse effects of intensive care unit (ICU) sedation has led to the use of strategies that target a "lighter" depth of sedation. Among these strategies are "analgosedation" protocols, which prioritize pain management and preferentially use IV opioids before administration of continuously...

journal_title：Anesthesia and analgesia

authors： Faust AC,Rajan P,Sheperd LA,Alvarez CA,McCorstin P,Doebele RL

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The inflated costs and documented deleterious effects of excess perioperative transfusion have led to the investigation of targeted coagulation factor replacement strategies. One particular coagulation factor of interest is factor I (fibrinogen). Hypofibrinogenemia is typically tested for using time-consumin...

journal_title：Anesthesia and analgesia

authors： Fabbro M 2nd,Gutsche JT,Miano TA,Augoustides JG,Patel PA

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Pathophysiologic changes in children with congenital heart disease may alter the effect of drugs by influencing the pharmacokinetics (PK). Considering the limited literature that describes the PK of etomidate in pediatric patients, especially in those with tetralogy of Fallot (TOF), our aim was to characteri...

journal_title：Anesthesia and analgesia

authors： Shen Y,Cai MH,Ji W,Bai J,Huang Y,Sun Y,Lin L,Niu J,Zhang MZ

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:In this study, we examined the relationship between postoperative cognitive dysfunction (POCD) and intraoperative regional cerebral oxygen saturation (rSO2) in elderly patients undergoing spinal surgery. METHODS:We enrolled 87 patients older than 65 years. All patients were tested using a battery of cogniti...

journal_title：Anesthesia and analgesia

authors： Kim J,Shim JK,Song JW,Kim EK,Kwak YL

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Cell-free hemoglobin (Hb) forms in stored red blood cells (RBCs) as a result of hemolysis. Studies suggest that this cell-free Hb may decrease nitric oxide (NO) bioavailability, potentially leading to endothelial dysfunction, vascular injury, and multiorgan dysfunction after transfusion. We tested the hypoth...

journal_title：Anesthesia and analgesia

authors： Nagababu E,Scott AV,Johnson DJ,Goyal A,Lipsitz JA,Barodka VM,Berkowitz DE,Frank SM

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The intrathecal morphine dose achieving optimal analgesia for cesarean delivery while minimizing side effects has not yet been deduced. In this meta-analysis, our objective was to determine whether low- or high-dose intrathecal morphine provides acceptable duration and intensity of analgesia with fewer side ...

journal_title：Anesthesia and analgesia

authors： Sultan P,Halpern SH,Pushpanathan E,Patel S,Carvalho B

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Previously, our group successfully established one of the nation's first Perioperative Surgical Homes (PSHs) aimed at coordinating services to patients undergoing primary total hip arthroplasty (THA) and primary total knee arthroplasty (TKA). As we now focus on extending the PSH to other service lines within...

journal_title：Anesthesia and analgesia

authors： Cyriac J,Garson L,Schwarzkopf R,Ahn K,Rinehart J,Vakharia S,Cannesson M,Kain Z

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:In 2001, the Center for Medicare and Medicaid Services issued a rule permitting states to "opt-out" of federal regulations requiring physician supervision of nurse anesthetists. We examined the extent to which this rule increased access to anesthesia care for urgent cases. METHODS:Using data from a national...

journal_title：Anesthesia and analgesia

authors： Sun E,Dexter F,Miller TR

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension and resulting right ventricular (RV) dysfunction are associated with significant perioperative morbidity and mortality. Although echocardiography permits real-time, noninvasive assessment of RV function, objective and comparative measures are underdeveloped, and appropriate animal mode...

journal_title：Anesthesia and analgesia

authors： Bartels K,Brown RD,Fox DL,Bull TM,Neary JM,Dorosz JL,Fonseca BM,Stenmark KR

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Although the mechanical status of the lungs affects the shape of the capnogram, the relations between the capnographic parameters and those reflecting the airway and lung tissue mechanics have not been established in mechanically ventilated patients. We, therefore, set out to characterize how the mechanical ...

journal_title：Anesthesia and analgesia

authors： Csorba Z,Petak F,Nevery K,Tolnai J,Balogh AL,Rarosi F,Fodor GH,Babik B

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Red blood cell (RBC) transfusion is common during infant cardiac surgery. A previous report of pediatric heart transplant recipients showed that increased RBC transfusion volume was independently associated with increased length of intensive care unit stay. It is unclear whether transfusion to infants as a s...

journal_title：Anesthesia and analgesia

authors： Carter HF,Lau C,Juma D,Wells B,Applegate RL 2nd

更新日期：2016-05-01 00:00:00

abstract：:Prothrombin complex concentrates (PCCs) contain vitamin K-dependent clotting factors (II, VII, IX, and X) and are marketed as 3 or 4 factor-PCC formulations depending on the concentrations of factor VII. PCCs rapidly restore deficient coagulation factor concentrations to achieve hemostasis, but like with all procoagul...

journal_title：Anesthesia and analgesia

authors： Ghadimi K,Levy JH,Welsby IJ

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Improved pain control after cesarean delivery remains a challenging objective. Poorly treated acute pain following delivery is associated with an increased risk of chronic pain and depression. This study was conducted to determine whether the addition of systemic acetaminophen and an increased dose of intrat...

journal_title：Anesthesia and analgesia

authors： Booth JL,Harris LC,Eisenach JC,Pan PH

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The extent to which insufflation of oxygen into the posterior pharynx during laryngoscopy prolongs adequate saturation in infants and small children remains unknown. Therefore, we compared oxygen saturation over time in preoxygenated small children with and without posterior pharynx oxygen insufflation. MET...

journal_title：Anesthesia and analgesia

authors： Windpassinger M,Plattner O,Gemeiner J,Röder G,Baumann A,Zimmerman NM,Sessler DI

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Unicondylar knee arthroplasty (UKA) is a commonly performed procedure with significant expected postoperative pain. Peripheral nerve blocks are 1 analgesic option, but some approaches may decrease quadriceps motor strength and interfere with early ambulation. In this study, we compared the analgesia provided...

journal_title：Anesthesia and analgesia

authors： Henshaw DS,Jaffe JD,Reynolds JW,Dobson S,Russell GB,Weller RS

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Xenon anesthesia has been studied for decades. However, no meta-analysis of randomized controlled trials (RCTs) on xenon anesthesia has been conducted. The aim of this study was to systematically review all available evidence from RCTs comparing xenon and other inhaled and IV anesthetics on anesthetic outcom...

journal_title：Anesthesia and analgesia

authors： Law LS,Lo EA,Gan TJ

更新日期：2016-03-01 00:00:00

abstract：:Outcomes after cardiac arrest remain poor more than a half a century after closed chest cardiopulmonary resuscitation (CPR) was first described. This review article is focused on recent insights into the physiology of blood flow to the heart and brain during CPR. Over the past 20 years, a greater understanding of hear...

journal_title：Anesthesia and analgesia

authors： Lurie KG,Nemergut EC,Yannopoulos D,Sweeney M

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Surgical site infiltration with local anesthetic reduces analgesic requests in various types of surgeries. Because thyroid surgery may induce severe postoperative pain, we tested the hypothesis that ropivacaine surgical site infiltration would significantly decrease postoperative administration of morphine i...

journal_title：Anesthesia and analgesia

authors： Miu M,Royer C,Gaillat C,Schaup B,Menegaux F,Langeron O,Riou B,Aubrun F

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:In patients with mitral regurgitation (MR), the effective regurgitant orifice area can be estimated by measuring the vena contracta area (VCA). We hypothesize that the VCA has characteristic temporal dynamics related to the underlying mechanism of functional mitral regurgitation (FMR) versus degenerative mit...

journal_title：Anesthesia and analgesia

authors： Cobey FC,Ashihkmina E,Edrich T,Fox J,Shook D,Bollen B,Breeze JL,Ursprung WW,Shernan SK

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:In this prospective observational study, we compared changes in cardiac index (CI) during fluid challenge using photoplethysmography (PPG; Nexfin™) (CIPPG) versus esophageal Doppler (ED) (CIED) in major noncardiac surgery patients. METHODS:Measurements were obtained when the attending anesthesiologist decid...

journal_title：Anesthesia and analgesia

authors： Blanié A,Soued M,Benhamou D,Mazoit JX,Duranteau J

更新日期：2016-02-01 00:00:00

abstract：:Successful procedural sedation represents a spectrum of patient- and clinician-related goals. The absence of a gold-standard measure of the efficacy of procedural sedation has led to a variety of outcomes being used in clinical trials, with the consequent lack of consistency among measures, making comparisons among tr...

journal_title：Anesthesia and analgesia

authors： Williams MR,McKeown A,Dexter F,Miner JR,Sessler DI,Vargo J,Turk DC,Dworkin RH

更新日期：2016-01-01 00:00:00

abstract：:Target-controlled infusion of IV anesthetic drugs is approved worldwide with the exception of the United States. The purpose of this special article is to review regulatory pathways that could lead to target-controlled infusion (TCI) clearance or approval in the United States. ...

journal_title：Anesthesia and analgesia

authors： Dryden PE

更新日期：2016-01-01 00:00:00